Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 12/20 | 0.51 |
| ▸ | EGFR | P00533 | 13/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172873 | 0.92 | ERBB2 (0.60) | ERBB2EGFRHDAC1HDAC6ERBB4 | |
| SCHEMBL6173815 | 0.91 | EGFR (0.53) | ERBB2EGFRHDAC3HDAC4HDAC1 | |
| SCHEMBL6177169 | 0.91 | ERBB2 (0.53) | ERBB2EGFRLCKHDAC3HDAC4 | |
| SCHEMBL6189113 | 0.90 | ERBB2 (0.51) | ERBB2EGFRLCKHDAC3HDAC4 | |
| SCHEMBL6175531 | 0.89 | ERBB2 (0.51) | ERBB2EGFRLCKHDAC3HDAC4 | |
| SCHEMBL6175719 | 0.89 | ERBB2 (0.57) | ERBB2EGFRLCKHDAC3HDAC4 | |
| SCHEMBL6173857 | 0.88 | ERBB2 (0.52) | ERBB2EGFRLCKHDAC3HDAC4 | |
| SCHEMBL6171826 | 0.88 | ERBB2 (0.62) | ERBB2EGFRLCKHDAC3HDAC4 | |
| SCHEMBL6177811 | 0.88 | ERBB2 (0.52) | ERBB2EGFRLCKHDAC3HDAC4 | |
| SCHEMBL6172769 | 0.87 | ERBB2 (0.52) | ERBB2EGFRLCKHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292591-B1 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PROD INC (US) | 2005-02-02 | — | — | EP | disclosed |