Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | BCR | P11274 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027346 | 0.91 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL3032853 | 0.90 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL3038308 | 0.89 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL3027663 | 0.82 | PDE4B (0.52) | PDE4BADORA2AADORA2BADORA1TBXAS1 | |
| SCHEMBL1653491 | 0.81 | PDE4B (0.54) | PDE4BABL1BCRGAAADORA2A | |
| SCHEMBL3022322 | 0.81 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL1652356 | 0.81 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL1654199 | 0.81 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DADORA1 | |
| SCHEMBL3029763 | 0.80 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL1651225 | 0.80 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-A1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058729-A1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL PRODESFARMA SA (ES) | 2004-07-15 | — | — | WO | disclosed |