SCHEMBL6178332

SCHEMBL6178332

Cn1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4cc5cc(N(CCCl)CCCl)ccc5o4)cn3C)cn2C)cc1C(=O)NCCC(N)=NO

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRAS P01112 13/20 0.83
ESR1 P03372 13/20 0.83
ESR2 Q92731 13/20 0.83
TOP1 P11387 2/20 0.42
MAPT P10636 3/20 0.42
KDM4E B2RXH2 1/20 0.42
POLB P06746 1/20 0.42
HIF1A Q16665 1/20 0.42
HDAC1 Q13547 3/20 0.35
HDAC2 Q92769 3/20 0.35
HDAC8 Q9BY41 3/20 0.35
HCRTR1 O43613 1/20 0.33
MAPK1 P28482 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HTT P42858 1/20 0.33
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC10 Q969S8 1/20 0.32
HDAC11 Q96DB2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6809704 0.91 HRAS (1.00) HRASESR1ESR2TOP1MAPT
Hydrochloric Acid SCHEMBL4618436 0.90 HRAS (1.00) HRASESR1ESR2TOP1MAPT
SCHEMBL14102117 0.90 HRAS (0.98) HRASESR1ESR2TOP1MAPT
SCHEMBL6175307 0.88 HRAS (0.86) HRASESR1ESR2TOP1MAPT
SCHEMBL7522868 0.85 HRAS (0.67) HRASESR1ESR2TOP1MAPT
SCHEMBL6178449 0.84 HRAS (0.83) HRASESR1ESR2TOP1MAPT
SCHEMBL6974763 0.83 HRAS (1.00) HRASESR1ESR2TOP1MAPT
Hydrochloric Acid SCHEMBL6974692 0.83 HRAS (1.00) HRASESR1ESR2TOP1MAPT
SCHEMBL8178732 0.82 HRAS (0.64) HRASESR1ESR2TOP1MAPT
SCHEMBL7814602 0.78 HRAS (0.51) HRASESR1ESR2MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1064281-B1 BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-05-25 EP claimed
US-6458768-B1 ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS PHARMACIA & UPJOHN, S.P.A. (IT) 2002-10-01 US claimed
EP-1064281-B1 BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-05-25 EP disclosed
US-6458768-B1 ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS PHARMACIA & UPJOHN, S.P.A. (IT) 2002-10-01 US disclosed