Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27565189 | 0.93 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL6175294 | 0.86 | MAPK14 (0.81) | MAPK14MAPK13MAPK12MAPK11POLB | |
| SCHEMBL6177123 | 0.85 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL6177800 | 0.84 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL7138257 | 0.84 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL6177992 | 0.82 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL6178461 | 0.82 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL6176847 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL6177360 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL7137877 | 0.81 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1326848-C | Aminopyrazole derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| CN-1331688-A | Aminopyridine Derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-01-16 | — | — | CN | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |