Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCH | P24723 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.31 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.31 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176228 | 1.00 | SPHK1 (0.42) | SPHK1SPHK2USP2HTTPRKD3 | |
| SCHEMBL8048384 | 0.93 | SPHK2 (0.37) | SPHK1SPHK2HSD17B10 | |
| SCHEMBL4885072 | 0.87 | HSD17B10 (0.33) | SPHK1SPHK2HSD17B10 | |
| SCHEMBL10119365 | 0.87 | SPHK1 (0.44) | SPHK1SPHK2USP2HTTPRKD3 | |
| SCHEMBL31086433 | 0.87 | SPHK1 (0.44) | SPHK1SPHK2USP2HTTPRKD3 | |
| SCHEMBL2152604 | 0.86 | SPHK1 (0.39) | SPHK1SPHK2USP2HTTPRKD3 | |
| SCHEMBL2152710 | 0.86 | SPHK1 (0.39) | SPHK1SPHK2USP2HTTPRKD3 | |
| SCHEMBL6654969 | 0.86 | SPHK1 (0.39) | SPHK1SPHK2USP2HTTPRKD3 | |
| SCHEMBL6650342 | 0.86 | SPHK1 (0.39) | SPHK1SPHK2USP2HTTPRKD3 | |
| SCHEMBL9149315 | 0.86 | SPHK1 (0.39) | SPHK1SPHK2USP2HTTPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945445-B9 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-0945445-B1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6239131-B1 | WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0945445-A1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |