Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178072 | 0.86 | MEN1 (0.41) | ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL31403308 | 0.76 | PRSS1 (0.37) | POLBALDH1A1 | |
| SCHEMBL7229706 | 0.72 | POLB (0.42) | LMNAGAAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2715883 | 0.72 | POLB (0.42) | LMNAGAAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7244851 | 0.70 | POLB (0.46) | LMNAGAAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7250534 | 0.70 | POLB (0.46) | LMNAGAAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8126885 | 0.70 | POLB (0.47) | LMNAGAAPOLBSMN1; SMN2NPC1 | |
| SCHEMBL30676280 | 0.69 | POLB (0.46) | LMNAGAAPOLBALDH1A1CYP2C19 | |
| SCHEMBL15390791 | 0.69 | POLB (0.46) | LMNAGAAPOLBALDH1A1CYP2C19 | |
| Alcohol SCHEMBL27538721 | 0.69 | POLB (0.44) | LMNAPOLBCYP2C19SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1061921-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1061921-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999045927-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-09-16 | — | — | WO | disclosed |