Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178426 | 0.91 | MAPK14 (0.56) | MAPK14KDM4EPTGDR2CSNK1DCSNK1E | |
| SCHEMBL4329813 | 0.91 | MAPK14 (0.56) | MAPK14ROCK1KDM4ECSNK1DCSNK1E | |
| SCHEMBL4329196 | 0.90 | MAPK14 (0.55) | MAPK14KDM4ECSNK1DCSNK1EEGFR | |
| SCHEMBL4338017 | 0.90 | MAPK14 (0.55) | MAPK14KDM4ECSNK1DCSNK1EEGFR | |
| SCHEMBL13785079 | 0.89 | MAPK14 (0.54) | MAPK14KDM4EPTGDR2CSNK1DCSNK1E | |
| SCHEMBL4338463 | 0.89 | MAPK14 (0.54) | MAPK14KDM4EPTGDR2CSNK1DCSNK1E | |
| SCHEMBL4339530 | 0.89 | MAPK14 (0.53) | MAPK14CSNK1DMAPT | |
| SCHEMBL7134239 | 0.88 | MAPK14 (0.52) | MAPK14KDM4EPTGDR2CSNK1DCSNK1E | |
| SCHEMBL6177398 | 0.88 | MAPK14 (0.52) | MAPK14KDM4ECSNK1DCSNK1EEGFR | |
| SCHEMBL6176508 | 0.88 | MAPK14 (0.52) | MAPK14KDM4ECSNK1DCSNK1EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |