Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180413 | 0.91 | ADORA2A (0.54) | ADORA2AADORA1CHRM4KMT2AMEN1 | |
| SCHEMBL6178935 | 0.90 | ADORA2A (0.53) | ADORA2AADORA1CHRM4KMT2AMEN1 | |
| SCHEMBL6178283 | 0.89 | ADORA2A (0.52) | ADORA2AADORA1CHRM4KMT2AMEN1 | |
| SCHEMBL6180137 | 0.89 | ADORA2A (0.52) | ADORA2AADORA1CHRM4KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6180228 | 0.89 | CHRM4 (0.51) | ADORA2AADORA1CHRM4KMT2AMAPT | |
| SCHEMBL6181250 | 0.88 | ADORA2A (0.51) | ADORA2AADORA1CHRM4KMT2AMEN1 | |
| SCHEMBL6179573 | 0.88 | ADORA2A (0.51) | ADORA2AADORA1CHRM4KMT2AMEN1 | |
| SCHEMBL5043994 | 0.88 | ADORA2A (0.51) | ADORA2AADORA1CHRM4KMT2AMEN1 | |
| SCHEMBL6181461 | 0.88 | CHRM4 (0.64) | ADORA2AADORA1CHRM4KMT2AMEN1 | |
| SCHEMBL6182887 | 0.87 | ADORA2A (0.51) | ADORA2AADORA1CHRM4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456202-B1 | BENZOTHIAZOLES | HOFFMANN LA ROCHE (CH) | 2005-11-09 | — | — | EP | disclosed |
| US-6734179-B2 | SULFUR COMPOUNDS SUCH AS 4-FLUORO-N-(4-METHOXY-7-(TETRAHYDRO-PYRAN-4-YL)-BENZOTHIAZOL-2-YL) -BENZAMIDE, USED AS PREFERENTIAL ADENOSINE RECEPTOR LIGANDS FOR THE PROPHYLAXIS OF NEURODEGENERATIVE DISORDERS | HOFFMANN-LA ROCHE INC. | 2004-05-11 | — | — | US | disclosed |