Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177933 | 0.90 | MAPK14 (0.47) | MAPK14MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6179329 | 0.86 | MAPK14 (0.46) | MAPK14MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4339540 | 0.85 | MAPK14 (0.48) | MAPK14MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6180611 | 0.81 | MAPK14 (0.48) | MAPK14MEN1KMT2AKDM4EGAA | |
| SCHEMBL4338919 | 0.78 | MAPK14 (0.46) | MAPK14KDM4EPTGDR2SRCBRAF | |
| SCHEMBL6176488 | 0.77 | MAPK14 (0.45) | MAPK14KDM4EPTGDR2PTGS2SRC | |
| SCHEMBL4335582 | 0.77 | SRC (0.50) | MAPK14PTGDR2SRCBRAFKDR | |
| SCHEMBL6178505 | 0.76 | ROCK1 (0.44) | MAPK14ALDH1A1SRCBRAFKDR | |
| SCHEMBL4329823 | 0.74 | MAPK14 (0.50) | MAPK14KDM4EPTGDR2SRCBRAF | |
| SCHEMBL6179749 | 0.74 | MAPK14 (0.50) | MAPK14KDM4EPTGDR2SRCBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |