SCHEMBL6180717

SCHEMBL6180717

COC(=O)c1ccc2cc[nH]c(=O)c2c1.COC(=O)c1ccc2ccn(CCOc3ccccc3)c(=O)c2c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.48
MAPT P10636 4/20 0.44
RAB9A P51151 1/20 0.44
TSHR P16473 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
ALDH1A1 P00352 4/20 0.39
HPGD P15428 3/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
GAA P10253 2/20 0.39
HTT P42858 2/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
KDM4E B2RXH2 4/20 0.39
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
EIF4EBP1 Q13541 2/20 0.38
ESR1 P03372 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6703820 0.91 MAPK1 (0.56) MAPK1MAPTRAB9ATSHRL3MBTL1
SCHEMBL2120728 0.83 MAPK1 (0.53) MAPK1MAPTRAB9AALDH1A1HPGD
SCHEMBL6702695 0.81 MEN1 (0.48) MAPK1ALDH1A1HPGDCYP2C9CYP2C19
SCHEMBL2118644 0.79 HDAC6 (0.46) MAPK1ALDH1A1HPGDCYP2C9CYP2C19
SCHEMBL2116182 0.78 MCL1 (0.53) MAPK1MAPTRAB9AALDH1A1HPGD
SCHEMBL1608799 0.78 MAPT (0.56) MAPK1MAPTRAB9ATSHRL3MBTL1
SCHEMBL30159669 0.77 KDM4E (0.48) RAB9AL3MBTL1ALDH1A1HPGDKMT2A
SCHEMBL2116289 0.77 KDM4E (0.48) RAB9AL3MBTL1ALDH1A1HPGDKMT2A
SCHEMBL6177449 0.76 PDPK1 (0.45) ALDH1A1HPGDSMN1; SMN2KDM4ECYP3A4
SCHEMBL6697485 0.76 KCNA5 (0.48) MAPTRAB9ATSHRALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530472-A1 ISOQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004014379-A1 ISOQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 WO disclosed