Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.39 |
| ▸ | PDE4A | P27815 | 14/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.37 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6182616 | 0.96 | PDE4A (0.39) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6796717 | 0.91 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6182856 | 0.91 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6180895 | 0.91 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6181117 | 0.90 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6181123 | 0.90 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6181114 | 0.90 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6179260 | 0.89 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6179254 | 0.89 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DTEAD1 | |
| SCHEMBL6179246 | 0.89 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DTEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912521-B1 | SUBSTITUTED INDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS PHOSPHODIESTERASE (PDE) TYPE IV AND THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | PFIZER (US) | 2005-04-06 | — | — | EP | claimed |