Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.60 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6292681 | 0.77 | MAPT (0.49) | MAPK14RIPK2MAPTUSP2KMT2A | |
| SCHEMBL4331951 | 0.76 | MAPK14 (0.58) | MAPK14MAPTKMT2AFYNSMN1; SMN2 | |
| SCHEMBL5475442 | 0.75 | MAPK13 (0.57) | MAPK14RIPK3MAPK1BRAFPOLB | |
| SCHEMBL6289177 | 0.75 | ADORA2A (0.54) | MAPK14RIPK2MAPTUSP2KMT2A | |
| SCHEMBL6076732 | 0.75 | MAPK14 (0.74) | MAPK14RIPK2MAPTSRCBRAF | |
| SCHEMBL6177947 | 0.75 | MAPK14 (1.00) | MAPK14RIPK2SRCBRAFKDR | |
| SCHEMBL6923809 | 0.74 | CA12 (0.54) | MAPTUSP2KMT2AFYNSMN1; SMN2 | |
| SCHEMBL4331198 | 0.73 | MAPK14 (0.52) | MAPK14MAPTKMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL13855026 | 0.72 | HTT (0.48) | MAPK14RIPK2MAPTUSP2KMT2A | |
| SCHEMBL16045349 | 0.72 | SMN1; SMN2 (0.46) | MAPK14RIPK3RIPK2MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |