SCHEMBL6181015

SCHEMBL6181015

c1coc([C@@H]2CCCN2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CHRM5 P08912 9/20 1.00
CHRM3 P20309 9/20 1.00
CHRM2 P08172 9/20 1.00
CHRM1 P11229 8/20 1.00
CHRM4 P08173 8/20 1.00
CHRNB2 P17787 2/20 0.46
CHRNA4 P43681 2/20 0.46
CHRNA7 P36544 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2349663 1.00 CHRM5 (1.00) CHRM5CHRM3CHRM2CHRM1CHRM4
Hydrochloric Acid SCHEMBL953398 0.98 CHRM5 (0.96) CHRM5CHRM3CHRM2CHRM1CHRM4
SCHEMBL7015792 0.94 CHRM5 (0.89) CHRM5CHRM3CHRM2CHRM1CHRM4
SCHEMBL9786179 0.76 CHRM5 (0.61) CHRM5CHRM3CHRM2CHRM1CHRM4
SCHEMBL3010648 0.76 CHRM5 (0.61) CHRM5CHRM3CHRM2CHRM1CHRM4
SCHEMBL7011586 0.75 CHRM5 (0.60) CHRM5CHRM3CHRM2CHRM1CHRM4
SCHEMBL16335774 0.74 CHRM5 (0.59) CHRM5CHRM3CHRM2CHRM1CHRM4
SCHEMBL7018605 0.73 CHRM5 (0.56) CHRM5CHRM3CHRM2CHRM1CHRM4
SCHEMBL22890955 0.73 CHRM5 (0.57) CHRM5CHRM3CHRM2CHRM1CHRM4
SCHEMBL18966709 0.73 CHRM5 (0.57) CHRM5CHRM3CHRM2CHRM1CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165510-B1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS HOFFMANN LA ROCHE (CH) 2005-09-28 EP disclosed
EP-1165510-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2002-01-02 EP disclosed
US-6284785-B1 HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS HOFFMANN- LA ROCHE INC. 2001-09-04 US disclosed
WO-2000058285-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2000-10-05 WO disclosed
EP-0971929-A1 2,3-DIHYDROFURO 3,2-$i(b)]PYRIDIN, PREPARATION AND APPLICATION THEREOF IN THERAPY SANOFI-SYNTHELABO (FR) 2000-01-19 EP disclosed
WO-1998042713-A1 2,3-DIHYDROFURO[3,2-b]PYRIDIN, PREPARATION AND APPLICATION THEREOF IN THERAPY SANOFI-SYNTHELABO (FR) 1998-10-01 WO disclosed