Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.64 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.61 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | F10 | P00742 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.53 |
| ▸ | LSS | P48449 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244233 | 0.88 | CHRM1 (0.67) | AKR1C3EIF2AK3F10LMNAALDH1A1 | |
| SCHEMBL6798769 | 0.82 | F10 (0.76) | F10LMNACHRM1LSSATM | |
| SCHEMBL1387210 | 0.81 | F10 (0.82) | F10LMNACHRM1LSSATM | |
| SCHEMBL6180931 | 0.81 | F10 (0.61) | AKR1C3EIF2AK3AKR1C1F10LMNA | |
| SCHEMBL15102072 | 0.80 | CHRM1 (0.79) | F10LMNACHRM1LSSATM | |
| SCHEMBL6791566 | 0.80 | F10 (0.60) | AKR1C3EIF2AK3AKR1C1F10LMNA | |
| SCHEMBL1387222 | 0.79 | TSHR (0.76) | F10LMNAALDH1A1MAPTCHRM1 | |
| SCHEMBL6787471 | 0.79 | F10 (0.59) | AKR1C3EIF2AK3AKR1C1F10LMNA | |
| SCHEMBL5246679 | 0.79 | AKR1C3 (1.00) | AKR1C3EIF2AK3AKR1C1LMNAKDM4E | |
| SCHEMBL1387218 | 0.79 | F10 (0.61) | AKR1C3EIF2AK3AKR1C1F10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844877-B1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ASTRAZENECA AB (SE) | 2005-01-26 | — | — | EP | disclosed |
| US-6090813-A | Use of oxido-squalene cyclase inhibitors to lower blood cholesterol | ZENECA LIMITED (GB) | 2000-07-18 | — | — | US | disclosed |
| EP-0844877-A1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997006802-A1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ZENECA LIMITED (GB) | 1997-02-27 | — | — | WO | disclosed |