Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494308 | 1.00 | BACE1 (0.41) | BACE1FLT3TGM2PDGFRBMAPT | |
| SCHEMBL4494303 | 1.00 | BACE1 (0.41) | BACE1FLT3TGM2PDGFRBMAPT | |
| SCHEMBL4499093 | 0.95 | BACE1 (0.39) | BACE1FLT3TGM2PDGFRBMAPT | |
| SCHEMBL4499092 | 0.95 | BACE1 (0.39) | BACE1FLT3TGM2PDGFRBMAPT | |
| SCHEMBL4499508 | 0.93 | BACE1 (0.41) | BACE1FLT3TGM2PDGFRBMAPT | |
| SCHEMBL4499513 | 0.93 | BACE1 (0.41) | BACE1FLT3TGM2PDGFRBMAPT | |
| SCHEMBL4482258 | 0.91 | BACE1 (0.39) | BACE1FLT3TGM2PDGFRBMAPT | |
| SCHEMBL4482260 | 0.91 | BACE1 (0.39) | BACE1FLT3TGM2PDGFRBMAPT | |
| SCHEMBL4487240 | 0.91 | BACE1 (0.38) | BACE1TGM2MAPTACHESMN1; SMN2 | |
| SCHEMBL4488158 | 0.91 | BACE1 (0.36) | BACE1FLT3TGM2PDGFRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1527046-A1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004009546-A1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-01-29 | — | — | WO | disclosed |