Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 19/20 | 0.73 |
| ▸ | ABL1 | P00519 | 4/20 | 0.73 |
| ▸ | BCR | P11274 | 3/20 | 0.73 |
| ▸ | FYN | P06241 | 3/20 | 0.73 |
| ▸ | EGFR | P00533 | 3/20 | 0.73 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.73 |
| ▸ | WEE1 | P30291 | 2/20 | 0.73 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.73 |
| ▸ | STK25 | O00506 | 1/20 | 0.73 |
| ▸ | CIT | O14578 | 1/20 | 0.73 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.73 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
| ▸ | CASK | O14936 | 1/20 | 0.73 |
| ▸ | GAK | O14976 | 1/20 | 0.73 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.73 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.73 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.73 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.73 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185394 | 0.92 | SRC (0.63) | SRCABL1BCRFYNEGFR | |
| SCHEMBL5251932 | 0.91 | SRC (0.68) | SRCABL1BCRFYNEGFR | |
| SCHEMBL6185902 | 0.89 | SRC (0.65) | SRCABL1BCRFYNEGFR | |
| SCHEMBL6184540 | 0.88 | SRC (0.74) | SRCABL1BCRFYNEGFR | |
| SCHEMBL5254607 | 0.88 | SRC (0.72) | SRCABL1BCRFYNEGFR | |
| SCHEMBL6183455 | 0.88 | SRC (0.74) | SRCABL1BCRFYNEGFR | |
| SCHEMBL5252220 | 0.87 | SRC (0.67) | SRCABL1BCRFYNEGFR | |
| SCHEMBL6185420 | 0.87 | SRC (0.67) | SRCABL1BCRFYNEGFR | |
| SCHEMBL5257261 | 0.86 | SRC (0.61) | SRCABL1BCRFYNEGFR | |
| SCHEMBL6186103 | 0.86 | SRC (0.70) | SRCABL1BCRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902029-B2 | CRYSTALLINE FORMS OF 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARB-ONITRILE AND METHODS OF PREPARING THE SAME | WYETH LLC (US) | 2022-02-16 | — | — | EP | claimed |
| EP-3002009-B1 | TREATMENT OF IMATINIB RESISTANT CHRONIC MYELOGENOUS LEUKEMIA HAVING THE MUTATON 1457T>C IN THE BCRABL GENE USING THE COMPOUND BOSUTINIB | WYETH LLC (US) | 2021-07-07 | — | — | EP | claimed |
| EP-1896020-B1 | SKI 606 as src kinase inhibitor for treating osteolytic lesions | UNIV TEXAS (US) | 2014-08-20 | — | — | EP | claimed |
| EP-2478905-B1 | Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles | WYETH LLC (US) | 2014-05-14 | — | — | EP | claimed |
| EP-1902029-B1 | CRYSTALLINE FORMS OF 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARB-ONITRILE AND METHODS OF PREPARING THE SAME | WYETH LLC (US) | 2014-01-08 | — | — | EP | claimed |
| EP-1499594-B1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES | WYETH CORP (US) | 2005-08-17 | — | — | EP | claimed |
| EP-3873532-A1 | DC-SIGN ANTIBODY DRUG CONJUGATES | Novartis AG (CH) | 2021-09-08 | — | — | EP | disclosed |