Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5448946 | 0.88 | MAPK14 (0.46) | MAPK14PTGS2PTGS1KDM4EADORA1 | |
| SCHEMBL5459562 | 0.86 | MAPK14 (0.44) | MAPK14PTGS2PTGS1KDM4ECSNK1D | |
| SCHEMBL5455132 | 0.86 | MAPK14 (0.48) | MAPK14PTGS2PTGS1KDM4EADORA1 | |
| SCHEMBL5457461 | 0.85 | MAPK14 (0.44) | MAPK14KDM4EDGAT2MAPT | |
| SCHEMBL5455164 | 0.84 | MAPK14 (0.48) | MAPK14PTGS2PTGS1KDM4ECSNK1D | |
| SCHEMBL5457274 | 0.83 | MAPK14 (0.46) | MAPK14KDM4EADORA1CSNK1DMAPT | |
| SCHEMBL5460496 | 0.82 | MAPK14 (0.46) | MAPK14KDM4EADORA1CSNK1DMAPT | |
| SCHEMBL5461798 | 0.80 | MAPK14 (0.53) | MAPK14CSNK1D | |
| SCHEMBL5462366 | 0.80 | MAPK14 (0.43) | MAPK14KDM4ECSNK1DMAPT | |
| SCHEMBL5455260 | 0.80 | MAPK14 (0.44) | MAPK14PTGS2PTGS1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377573-B1 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-07-27 | — | — | EP | claimed |