Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6338970 | 0.88 | CDK5 (0.59) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6183492 | 0.86 | GSK3B (0.51) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6106995 | 0.86 | EIF2AK2 (0.50) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6106606 | 0.86 | EIF2AK2 (0.50) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6182597 | 0.85 | GSK3B (0.49) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6105305 | 0.85 | EIF2AK2 (0.51) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6069055 | 0.85 | GSK3B (0.55) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL14592155 | 0.84 | GSK3B (0.49) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6108267 | 0.83 | GSK3B (0.51) | GSK3BCDK5PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6183945 | 0.81 | GSK3B (0.61) | GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341788-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2005-08-10 | — | — | EP | claimed |
| US-20040072853-A1 | Therapeutic compounds | CHAMBERLAIN STANLEY D (US) | 2004-04-15 | — | — | US | claimed |
| US-7160897-B2 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| US-7160897-B2 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| EP-1341788-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2005-08-10 | — | — | EP | disclosed |
| US-6919352-B2 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-19 | — | — | US | disclosed |
| US-20040072853-A1 | Therapeutic compounds | CHAMBERLAIN STANLEY D (US) | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072853-A1 | Therapeutic compounds | PCSK9, ABCB1, FURIN | GSK3B 1270/4885CDK5 1272/4885PIK3CA 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.