Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325571 | 0.76 | RAF1 (0.47) | KDREGFRFGFR1 | |
| SCHEMBL4238744 | 0.75 | MEN1 (0.57) | MAPK14LMNAHSP90AA1MAPTHTT | |
| SCHEMBL4081981 | 0.74 | MAPK14 (0.58) | MAPK14EGFRHSP90AA1 | |
| SCHEMBL4081496 | 0.74 | MAPK14 (0.58) | MAPK14 | |
| SCHEMBL1599556 | 0.74 | MAPK14 (0.70) | MAPK14ABCB1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1492785 | 0.73 | PSEN1 (0.57) | MAPK14LMNAHSP90AA1MAPTHTT | |
| SCHEMBL1911847 | 0.72 | NPC1 (0.65) | CYP1A2CYP3A4LMNAMAPTSLC2A1 | |
| SCHEMBL6639189 | 0.71 | MAPK14 (0.67) | MAPK14LMNAMAPTRECQL | |
| SCHEMBL16106825 | 0.71 | HTT (0.61) | MAPK14CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL26324280 | 0.71 | MAPK14 (0.61) | MAPK14CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042305-B1 | INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS | BAYER PHARMACEUTICALS CORP (US) | 2005-06-08 | — | — | EP | claimed |