Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023531 | 0.93 | NPSR1 (0.54) | NPSR1ALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL27603528 | 0.86 | NPSR1 (0.50) | NPSR1ALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL4023532 | 0.80 | NPSR1 (0.44) | NPSR1ALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL4183708 | 0.74 | TSHR (0.45) | ALDH1A1TDP1MAPTF2PRSS1 | |
| SCHEMBL15284094 | 0.71 | NPSR1 (0.59) | NPSR1ALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL8331183 | 0.69 | NPSR1 (0.60) | NPSR1ALDH1A1TDP1HSD17B10HTT | |
| SCHEMBL11427505 | 0.69 | NPSR1 (0.51) | NPSR1ALDH1A1TDP1HSD17B10KMT2A | |
| SCHEMBL2956140 | 0.69 | NPSR1 (0.60) | NPSR1ALDH1A1TDP1HSD17B10HTT | |
| SCHEMBL27622387 | 0.68 | TSHR (0.42) | ALDH1A1TDP1MAPTF2PRSS1 | |
| SCHEMBL5964871 | 0.68 | NPSR1 (0.59) | NPSR1ALDH1A1TDP1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022529-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |