Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209155 | 0.93 | KDR (0.53) | KDRINSRMETFGFR1DGAT2 | |
| SCHEMBL5210223 | 0.86 | KDR (0.45) | KDRFGFR1DGAT2MAPK10EGFR | |
| SCHEMBL5210274 | 0.86 | KDR (0.48) | KDRINSRMETNPC1FGFR1 | |
| SCHEMBL6186147 | 0.85 | KDR (0.41) | KDRFGFR1DGAT2MAPK10GRM4 | |
| SCHEMBL5213440 | 0.85 | KDR (0.44) | KDRFGFR1DGAT2MAPK10PDPK1 | |
| SCHEMBL14527935 | 0.85 | KDR (0.43) | KDRMETFGFR1DGAT2MAPK10 | |
| SCHEMBL5208093 | 0.84 | KDR (0.42) | KDRFGFR1DGAT2MAPK10EGFR | |
| SCHEMBL5208752 | 0.82 | KDM4E (0.39) | KDRSMN1; SMN2DGAT2MAPK10GRM4 | |
| SCHEMBL5205099 | 0.82 | KDR (0.38) | KDRFGFR1DGAT2MAPK10 | |
| SCHEMBL5210055 | 0.82 | KDR (0.41) | KDRFGFR1DGAT2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585743-A1 | 2-(1H-INDAZOL-6-YLAMINO)- BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTHALMIC DISEASES | PFIZER INC. (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004056806-A1 | 2-(1H-INDAZOL-6-YLAMINO)-BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTALMIC DISEASES | PFIZER INC. (US) | 2004-07-08 | — | — | WO | disclosed |