Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.59 |
| ▸ | ABL1 | P00519 | 10/20 | 0.59 |
| ▸ | CDK1 | P06493 | 8/20 | 0.59 |
| ▸ | SRC | P12931 | 9/20 | 0.59 |
| ▸ | PRKCA | P17252 | 7/20 | 0.58 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188950 | 0.99 | EGFR (0.58) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL6185571 | 0.96 | EGFR (0.60) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL6187695 | 0.94 | EGFR (0.55) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL6187365 | 0.94 | EGFR (0.54) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL6188882 | 0.90 | EGFR (0.55) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL8579739 | 0.89 | EGFR (0.69) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL8578273 | 0.88 | EGFR (0.70) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL6187847 | 0.87 | EGFR (0.65) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL6187292 | 0.86 | EGFR (0.64) | EGFRABL1CDK1SRCPRKCA | |
| SCHEMBL6186182 | 0.86 | EGFR (0.64) | EGFRABL1CDK1SRCPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |
| EP-0929553-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014450-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | disclosed |