Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616817 | 0.92 | NAALAD2 (0.45) | NAALAD2ATMCYP1A1CNR1CNR2 | |
| SCHEMBL6185880 | 0.90 | NAALAD2 (0.43) | NAALAD2LTA4HATMCYP1A1CNR1 | |
| SCHEMBL5742305 | 0.83 | KMT2A (0.41) | NAALAD2ATMCYP1A1CNR1CNR2 | |
| SCHEMBL6615392 | 0.82 | CNR1 (0.36) | NAALAD2ATMCNR1CNR2KMT2A | |
| SCHEMBL6616814 | 0.81 | NAALAD2 (0.45) | NAALAD2ATMCYP1A1CNR1CNR2 | |
| SCHEMBL6617401 | 0.81 | ACE (0.46) | NAALAD2CNR1CNR2 | |
| SCHEMBL2942452 | 0.79 | CNR1 (0.37) | NAALAD2ATMCNR1CNR2KMT2A | |
| SCHEMBL6618141 | 0.77 | KMT2A (0.42) | NAALAD2ATMCNR1CNR2ANPEP | |
| SCHEMBL6613646 | 0.77 | FOLH1 (0.39) | NAALAD2ATMCNR1CNR2ANPEP | |
| SCHEMBL4808140 | 0.77 | FOLH1 (0.54) | NAALAD2ATMCYP1A1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521742-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| EP-1427423-A1 | BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT HYPERLIPIDAEMIA | AstraZeneca AB (SE) | 2004-06-16 | — | — | EP | disclosed |
| WO-2004005247-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |
| WO-2003022286-A1 | BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT HYPERLIPIDAEMIA | ASTRAZENECA AB (SE) | 2003-03-20 | — | — | WO | disclosed |