Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.67 |
| ▸ | MAP2K2 | P36507 | 10/20 | 0.67 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 4/20 | 0.53 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.53 |
| ▸ | STK3 | Q13188 | 1/20 | 0.53 |
| ▸ | MAP3K9 | P80192 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4860159 | 0.85 | MAP2K1 (0.75) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL4861840 | 0.82 | MAP2K1 (0.70) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL4860207 | 0.82 | MAP2K1 (0.70) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL30505247 | 0.80 | MAP2K1 (1.00) | MAP2K1MAP2K2IDO1BRAFMAPK1 | |
| SCHEMBL29413559 | 0.80 | MAP2K1 (1.00) | MAP2K1MAP2K2IDO1BRAFMAPK1 | |
| SCHEMBL188505 | 0.80 | MAP2K1 (1.00) | MAP2K1MAP2K2IDO1BRAFMAPK1 | |
| SCHEMBL1562380 | 0.80 | MAP2K1 (0.67) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL29425373 | 0.80 | MAP2K1 (0.67) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| Hydrochloric Acid SCHEMBL30080174 | 0.79 | MAP2K1 (0.97) | MAP2K1MAP2K2IDO1BRAFMAPK1 | |
| SCHEMBL1562726 | 0.79 | MAP2K1 (0.65) | MAP2K1MAP2K2IDO1AURKATNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | disclosed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | MAPK1, MAP3K1, MAPK3 | MAP2K1 46/4885MAP2K2 40/4885IDO1 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.