SCHEMBL6186544

SCHEMBL6186544

O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1Oc1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MTTP P55157 11/20 0.72
CHRM2 P08172 1/20 0.72
ADRA2A P08913 1/20 0.72
ADORA3 P0DMS8 1/20 0.72
CHRM1 P11229 1/20 0.72
DRD1 P21728 1/20 0.72
TBXA2R P21731 1/20 0.72
PTGS1 P23219 1/20 0.72
SLC6A2 P23975 1/20 0.72
ADRA1A P35348 1/20 0.72
OPRM1 P35372 1/20 0.72
DRD3 P35462 1/20 0.72
SLC6A3 Q01959 1/20 0.72
KCNH2 Q12809 1/20 0.72
MTR Q99707 1/20 0.72
CCR3 P51677 1/20 0.50
OPRK1 P41145 1/20 0.46
OPRL1 P41146 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8898104 0.95 MTTP (0.66) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL8898374 0.95 MTTP (0.66) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL8895351 0.95 MTTP (0.66) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL6188622 0.93 MTTP (0.62) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL8892179 0.92 MTTP (0.61) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL6187452 0.92 MTTP (0.61) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL474074 0.90 MTTP (0.78) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL6187816 0.90 MTTP (0.57) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL6188492 0.89 MTTP (0.57) MTTPCHRM2ADRA2AADORA3CHRM1
SCHEMBL7157393 0.88 MTTP (0.70) MTTPCHRM2ADRA2AADORA3CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0886637-B9 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL MYERS SQUIBB CO (US) 2005-05-04 EP claimed
EP-0886637-B1 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL MYERS SQUIBB CO (US) 2004-12-01 EP claimed
EP-0886637-A4 1998-12-30 EP claimed
EP-0886637-A1 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 1998-12-30 EP claimed
WO-1996026205-A1 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 1996-08-29 WO claimed
EP-0886637-B9 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL MYERS SQUIBB CO (US) 2005-05-04 EP disclosed
EP-0886637-B1 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL MYERS SQUIBB CO (US) 2004-12-01 EP disclosed
US-6066650-A USEFUL FOR LOWERING SERUM LIPIDS AND TREATING ATHEROSCLEROSIS AND RELATED DISEASES BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-23 US disclosed
US-6034098-A ATHEROSCLEROSIS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-03-07 US disclosed
EP-0886637-A1 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 1998-12-30 EP disclosed
EP-0886637-A4 1998-12-30 EP disclosed
WO-1996026205-A1 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 1996-08-29 WO disclosed