Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 11/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206971 | 0.95 | MAP2K1 (0.38) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL6206974 | 0.92 | MAP2K1 (0.47) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL6186547 | 0.91 | MAP2K1 (0.39) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL6206196 | 0.83 | IRAK4 (0.34) | MAP2K1MAP2K2 | |
| SCHEMBL6190111 | 0.82 | MAP2K1 (0.42) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL6189159 | 0.82 | MAP2K1 (0.42) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL6191826 | 0.81 | MAP2K1 (0.38) | MAP2K1MAP2K2 | |
| SCHEMBL6397573 | 0.79 | RXFP1 (0.33) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL6188842 | 0.79 | GSK3B (0.33) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL6186539 | 0.79 | MAP2K1 (0.48) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | claimed |