Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 10/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190456 | 0.84 | MAP2K1 (0.47) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL6187974 | 0.82 | MAP2K1 (0.53) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL5989634 | 0.80 | MAP2K1 (0.66) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL6187595 | 0.78 | MAP2K1 (0.42) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL6319695 | 0.78 | MAP2K1 (0.50) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL5989889 | 0.76 | MAP2K1 (0.75) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL6188534 | 0.76 | MAP2K1 (0.48) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL5992019 | 0.75 | MAP2K1 (0.54) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 | |
| SCHEMBL6313978 | 0.74 | MAP2K1 (0.45) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL6315452 | 0.74 | MAP2K1 (0.46) | MAP2K1MAP2K2PIM1CAMK2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | disclosed |