SCHEMBL6187590

SCHEMBL6187590

O=c1cc(NC2CCN(CCc3ccc4ccccc4c3)CC2)c2cc(Cl)ccc2o1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 19/20 0.83
KCNH2 Q12809 4/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6314274 0.91 MCHR1 (1.00) MCHR1KCNH2
SCHEMBL6191377 0.88 MCHR1 (0.65) MCHR1KCNH2
SCHEMBL6192311 0.88 MCHR1 (0.64) MCHR1KCNH2
SCHEMBL6189202 0.85 MCHR1 (0.83) MCHR1KCNH2
SCHEMBL6187685 0.82 MCHR1 (0.81) MCHR1KCNH2
SCHEMBL6313161 0.81 MCHR1 (0.79) MCHR1KCNH2
SCHEMBL6306074 0.80 MCHR1 (0.79) MCHR1KCNH2
SCHEMBL6207682 0.80 MCHR1 (0.74) MCHR1KCNH2
SCHEMBL6305718 0.79 MCHR1 (0.78) MCHR1KCNH2
SCHEMBL6187989 0.78 MCHR1 (0.77) MCHR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534703-A2 ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR ABBOTT LABORATORIES (US) 2005-06-01 EP disclosed
WO-2003106452-A2 ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR MILLENNIUM PHARMACEUTICALS, INC. (US) 2003-12-24 WO disclosed