Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | LIFR | P42702 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435943 | 0.87 | NR1H4 (0.66) | NR1H4LIFR | |
| SCHEMBL4433150 | 0.87 | NR1H4 (0.66) | NR1H4LIFR | |
| SCHEMBL4831011 | 0.83 | NR1H4 (0.67) | NR1H4LIFR | |
| SCHEMBL4840166 | 0.81 | NR1H4 (0.68) | NR1H4LIFR | |
| SCHEMBL4422439 | 0.81 | NR1H4 (0.68) | NR1H4LIFR | |
| SCHEMBL4628411 | 0.80 | NR1H4 (0.69) | NR1H4LIFR | |
| SCHEMBL4840153 | 0.80 | NR1H4 (0.66) | NR1H4LIFR | |
| SCHEMBL4427382 | 0.80 | NR1H4 (0.69) | NR1H4LIFR | |
| SCHEMBL4877436 | 0.79 | NR1H4 (0.58) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4838752 | 0.79 | NR1H4 (0.70) | NR1H4LIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562915-A1 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004048349-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |