Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.61 |
| ▸ | CDK1 | P06493 | 11/20 | 0.61 |
| ▸ | SRC | P12931 | 11/20 | 0.61 |
| ▸ | ABL1 | P00519 | 15/20 | 0.60 |
| ▸ | PRKCA | P17252 | 8/20 | 0.60 |
| ▸ | ABL2 | P42684 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541729 | 0.86 | EGFR (0.51) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL4531293 | 0.86 | EGFR (0.57) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6188036 | 0.86 | EGFR (0.64) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8115748 | 0.84 | EGFR (0.77) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8122758 | 0.83 | EGFR (0.61) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187995 | 0.83 | EGFR (0.66) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187497 | 0.82 | EGFR (0.58) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8124691 | 0.82 | CDK1 (0.76) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6189468 | 0.82 | EGFR (0.61) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6185719 | 0.82 | EGFR (0.59) | EGFRCDK1SRCABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |