SCHEMBL6188420

SCHEMBL6188420

CCCc1cc2c(C(F)(F)F)onc2c(CCC)c1OC(C(=O)O)c1ccc(CC(C)C)cc1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 19/20 0.61
PPARA Q07869 19/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6183969 0.91 PPARG (0.72) PPARGPPARA
SCHEMBL6183795 0.89 PPARG (0.71) PPARGPPARA
SCHEMBL6185082 0.89 PPARG (0.72) PPARGPPARA
SCHEMBL6185576 0.86 PPARG (0.58) PPARGPPARA
SCHEMBL13924125 0.85 PPARA (0.84) PPARGPPARA
SCHEMBL4013170 0.85 PPARA (0.84) PPARGPPARA
SCHEMBL6183260 0.84 PPARG (0.56) PPARGPPARA
SCHEMBL6184321 0.83 PPARG (0.60) PPARGPPARA
SCHEMBL6186461 0.81 PPARG (0.61) PPARGPPARA
SCHEMBL4014090 0.80 PPARA (0.73) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1366012-A4 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS MERCK & CO INC (US) 2005-11-02 EP claimed
EP-1366012-A2 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS Merck & Co., Inc. (US) 2003-12-03 EP claimed
WO-2002064094-A2 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS MERCK & CO., INC. (US) 2002-08-22 WO claimed
EP-1366012-A4 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS MERCK & CO INC (US) 2005-11-02 EP disclosed
EP-1366012-A2 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS Merck & Co., Inc. (US) 2003-12-03 EP disclosed
WO-2002064094-A2 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS MERCK & CO., INC. (US) 2002-08-22 WO disclosed