Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29317762 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2USP2PKMFKBP1ATSHR | |
| SCHEMBL4176542 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2USP2PKMTSHRALDH1A1 | |
| SCHEMBL5986955 | 0.74 | SMN1; SMN2 (0.53) | SMN1; SMN2USP2PKMFKBP1ATSHR | |
| SCHEMBL8392706 | 0.74 | SMN1; SMN2 (0.53) | SMN1; SMN2USP2PKMTSHRALDH1A1 | |
| SCHEMBL14433020 | 0.73 | SMN1; SMN2 (0.52) | SMN1; SMN2USP2PKMFKBP1ATSHR | |
| SCHEMBL12308627 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2USP2PKMFKBP1ATSHR | |
| SCHEMBL17323928 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2USP2PKMFKBP1ATSHR | |
| SCHEMBL8749086 | 0.72 | SMN1; SMN2 (0.55) | SMN1; SMN2USP2PKMTSHRALDH1A1 | |
| SCHEMBL800634 | 0.72 | SMN1; SMN2 (0.55) | SMN1; SMN2USP2PKMTSHRALDH1A1 | |
| SCHEMBL26790796 | 0.70 | SMN1; SMN2 (0.49) | SMN1; SMN2USP2PKMFKBP1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567489-A1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004052851-A1 | PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2004-06-24 | — | — | WO | disclosed |