Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11655675 | 0.84 | HPGD (0.57) | HPGDCNR1MEN1KMT2AGAA | |
| SCHEMBL7351625 | 0.84 | HPGD (0.72) | HPGDCNR1MEN1KMT2AGAA | |
| SCHEMBL11196742 | 0.81 | HPGD (0.54) | HPGDCNR1MEN1KMT2AGAA | |
| SCHEMBL15709116 | 0.79 | NPC1 (0.54) | HPGDCNR1MEN1KMT2AGAA | |
| SCHEMBL1261177 | 0.79 | HPGD (0.51) | HPGDCNR1MEN1KMT2AGAA | |
| SCHEMBL19369524 | 0.79 | SMN1; SMN2 (0.58) | MEN1KMT2AALDH1A1ATMLMNA | |
| SCHEMBL1261180 | 0.79 | HPGD (0.51) | HPGDCNR1MEN1KMT2AGAA | |
| Sulfurous Acid SCHEMBL28752566 | 0.78 | KMT2A (0.49) | HPGDCNR1MEN1KMT2AGAA | |
| SCHEMBL28781135 | 0.78 | HPGD (0.50) | HPGDCNR1MEN1KMT2AGAA | |
| SCHEMBL28944511 | 0.77 | CNR1 (0.51) | HPGDCNR1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804437-B1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 2005-09-14 | — | — | EP | disclosed |
| US-5939415-A | A!-annellated pyrrole derivatives and their use in pharmacology | MERCKLE GMBH (DE) | 1999-08-17 | — | — | US | disclosed |
| EP-0804437-A1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| WO-1995032971-A1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 1995-12-07 | — | — | WO | disclosed |