SCHEMBL6189368

SCHEMBL6189368

Cc1cccc2[nH]c(NC(=O)CCBr)nc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 2/20 0.47
MMP9 P14780 2/20 0.47
MMP8 P22894 2/20 0.47
NPC1 O15118 6/20 0.47
RAB9A P51151 6/20 0.47
ALDH1A1 P00352 4/20 0.47
SMN1; SMN2 Q16637 4/20 0.47
HPSE Q9Y251 2/20 0.47
TP53 P04637 2/20 0.46
SPHK2 Q9NRA0 1/20 0.46
SPHK1 Q9NYA1 1/20 0.46
KDM4E B2RXH2 1/20 0.46
HPGD P15428 1/20 0.46
HSD17B10 Q99714 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
MMP13 P45452 1/20 0.46
MAPT P10636 1/20 0.44
MAOB P27338 2/20 0.43
ADORA2A P29274 2/20 0.43
ADORA2B P29275 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3413861 0.82 HPSE (0.55) MMP2MMP9MMP8NPC1RAB9A
Hydrochloric Acid SCHEMBL11576683 0.80 HPSE (0.53) MMP2MMP9MMP8NPC1RAB9A
SCHEMBL4900862 0.78 ADORA2A (0.52) NPC1RAB9AALDH1A1SMN1; SMN2HPSE
Phosphoric Acid SCHEMBL11576943 0.77 MAOB (0.51) MMP2MMP9MMP8NPC1RAB9A
Sulfuric Acid SCHEMBL11575852 0.77 HPSE (0.50) MMP2MMP9MMP8NPC1RAB9A
SCHEMBL6709743 0.76 KMT2A (0.58) NPC1RAB9AALDH1A1SMN1; SMN2TP53
SCHEMBL11703118 0.76 MAOB (0.71) NPC1RAB9ASMN1; SMN2HPSETP53
Nitric Acid SCHEMBL11577224 0.75 MGAM (0.48) MMP2MMP9MMP8NPC1RAB9A
SCHEMBL6972586 0.73 HPSE (0.46) NPC1RAB9AALDH1A1SMN1; SMN2HPSE
Hydrochloric Acid SCHEMBL11789101 0.72 HPSE (0.45) NPC1RAB9AALDH1A1SMN1; SMN2HPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1505968-A1 MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES ELI LILLY AND COMPANY (US) 2005-02-16 EP disclosed
WO-2003097047-A1 MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES ELI LILLY AND COMPANY (US) 2003-11-27 WO disclosed