Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017737 | 0.85 | CCR1 (0.61) | CCR1 | |
| SCHEMBL27764747 | 0.83 | CCR1 (0.49) | CCR1MAPTGFERSMN1; SMN2TSHR | |
| SCHEMBL27764744 | 0.78 | CCR1 (0.54) | CCR1MAPTGFERSMN1; SMN2TSHR | |
| SCHEMBL4019904 | 0.77 | CCR1 (0.53) | CCR1MAPTLMNAALDH1A1 | |
| SCHEMBL6186440 | 0.76 | CCR1 (0.48) | CCR1 | |
| SCHEMBL4015187 | 0.75 | CCR1 (0.49) | CCR1MAPTSMN1; SMN2LMNA | |
| SCHEMBL4015911 | 0.74 | CCR1 (0.54) | CCR1 | |
| SCHEMBL4016493 | 0.74 | CCR1 (0.39) | CCR1MAPTTSHRPOLBLMNA | |
| SCHEMBL4019875 | 0.74 | CCR1 (0.45) | CCR1 | |
| SCHEMBL2875554 | 0.73 | CCR1 (0.74) | CCR1MAPTTSHRTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531822-A1 | 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | Chemocentryx, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2003105853-A1 | 1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | CHEMOCENTRYX, INC. (US) | 2003-12-24 | — | — | WO | disclosed |