Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6191542 | 0.81 | CCNA2 (0.46) | CCNA2CDK2KMT2AMAPTALDH1A1 | |
| SCHEMBL3829101 | 0.79 | KMT2A (0.50) | CNR2CCNA2CDK2KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL27594585 | 0.77 | KMT2A (0.49) | CNR2CCNA2CDK2KMT2AMAPT | |
| SCHEMBL1683594 | 0.77 | HDAC1 (0.64) | HDAC1HDAC8HDAC6HPGDSKMT2A | |
| SCHEMBL6191028 | 0.75 | CCNA2 (0.67) | CCNA2CDK2KMT2AGSK3BCDK5 | |
| SCHEMBL16039880 | 0.72 | CCNA2 (0.65) | CCNA2CDK2KMT2AMAPTTDP1 | |
| SCHEMBL6190685 | 0.72 | MAPT (0.62) | KMT2AMAPTALDH1A1GAAMAPK1 | |
| SCHEMBL4455537 | 0.71 | KMT2A (0.52) | CNR2HPGDSKMT2AMAPTALDH1A1 | |
| SCHEMBL1669181 | 0.71 | KMT2A (0.52) | CNR2HPGDSKMT2AMAPTALDH1A1 | |
| SCHEMBL4455543 | 0.69 | KMT2A (0.50) | HDAC1HDAC8HDAC6CNR2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181283-B1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMA (US) | 2005-02-02 | — | — | EP | disclosed |
| US-6620828-B2 | Antiproliferative agents | AGOURON PHARMACEUTICALS, INC. | 2003-09-16 | — | — | US | disclosed |
| US-20020025976-A1 | Thiazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2002-02-28 | — | — | US | disclosed |
| EP-1181283-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075120-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025976-A1 | Thiazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use | BRAF, CDK2, CHUK | HDAC1 1492/4885HDAC8 2520/4885HDAC6 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.