SCHEMBL6189562

SCHEMBL6189562

O=CCc1ccc(Nc2c(-c3nnc(NCCN4CCOCC4)o3)ccc(F)c2F)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 12/20 0.44
KCNH2 Q12809 11/20 0.44
CHRNA1 P02708 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CHRNB2 P17787 1/20 0.43
CYP2C19 P33261 1/20 0.43
CHRNA4 P43681 1/20 0.43
MAP3K8 P41279 1/20 0.42
SIGMAR1 Q99720 2/20 0.41
MAPK14 Q16539 1/20 0.38
CSF1R P07333 1/20 0.38
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MAP2K2 P36507 1/20 0.36
MAP2K1 Q02750 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6403862 0.91 CHRNA7 (0.42) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL6399220 0.90 CHRNA7 (0.43) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL6190172 0.89 CHRNA7 (0.44) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL6190835 0.87 CHRNA7 (0.45) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL29371646 0.86 MAP2K2 (0.47) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL15598681 0.86 CHRNA7 (0.44) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL6207045 0.86 MAP2K2 (0.47) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL6206530 0.86 CHRNA7 (0.43) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL6403620 0.85 CHRNA7 (0.48) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4
SCHEMBL6189558 0.85 CHRNA7 (0.51) CHRNA7KCNH2CHRNA1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1578736-A1 MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES Warner-Lambert Company LLC (US) 2005-09-28 EP disclosed
WO-2004056789-A1 MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES WARNER-LAMBERT COMPANY LLC (US) 2004-07-08 WO disclosed