Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193353 | 1.00 | CYP2D6 (0.49) | CYP2D6CYP2C9CYP2C19RECQLSMN1; SMN2 | |
| SCHEMBL6194780 | 1.00 | CYP2D6 (0.49) | CYP2D6CYP2C9CYP2C19RECQLSMN1; SMN2 | |
| SCHEMBL6193349 | 1.00 | CYP2D6 (0.49) | CYP2D6CYP2C9CYP2C19RECQLSMN1; SMN2 | |
| SCHEMBL6190821 | 1.00 | CYP2D6 (0.49) | CYP2D6CYP2C9CYP2C19RECQLSMN1; SMN2 | |
| SCHEMBL2780433 | 1.00 | CYP2D6 (0.49) | CYP2D6CYP2C9CYP2C19RECQLSMN1; SMN2 | |
| SCHEMBL7173228 | 0.96 | ITGB1 (0.48) | CYP2D6CYP2C9CYP2C19RECQLSMN1; SMN2 | |
| SCHEMBL6751575 | 0.85 | TACR1 (0.51) | CYP2D6CYP2C9CYP2C19RECQLALDH1A1 | |
| SCHEMBL6370800 | 0.85 | TACR1 (0.51) | CYP2D6CYP2C9CYP2C19RECQLALDH1A1 | |
| SCHEMBL27462559 | 0.85 | TACR1 (0.51) | CYP2D6CYP2C9CYP2C19RECQLALDH1A1 | |
| SCHEMBL25453255 | 0.84 | CYP2D6 (0.52) | CYP2D6CYP2C9CYP2C19RECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299365-B1 | 2-AMINOTHIAZOLINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2005-09-28 | — | — | EP | disclosed |
| EP-1299365-A1 | 2-AMINOTHIAZOLINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | Aventis Pharma S.A. (FR) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001094325-A1 | 2-AMINOTHIAZOLINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2001-12-13 | — | — | WO | disclosed |