SCHEMBL6192258

SCHEMBL6192258

CC(C)(C)OC(=O)NCc1cccc(C(O)c2cc(Cl)ccc2NCCc2ccc(OCc3ccccc3)cc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.44
BCL2 P10415 2/20 0.41
BCHE P06276 1/20 0.41
GID4 Q8IVV7 1/20 0.40
POLB P06746 2/20 0.40
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
ALOX12 P18054 1/20 0.40
HTT P42858 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MEN1 O00255 1/20 0.39
MAPK1 P28482 1/20 0.39
KMT2A Q03164 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
PSMB1 P20618 1/20 0.38
PSMB8 P28062 1/20 0.38
PSMB9 P28065 1/20 0.38
PSMB5 P28074 1/20 0.38
ADRB3 P13945 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6192565 0.95 BCL2 (0.46) HDAC1BCL2BCHEGID4POLB
SCHEMBL6190392 0.86 MEN1 (0.43) HDAC1POLBNPC1ALDH1A1HTT
SCHEMBL6189547 0.85 MRGPRX4 (0.41) HDAC1HTTNPSR1
SCHEMBL6189178 0.84 PTGER1 (0.43) POLBNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL6188632 0.84 BCHE (0.42) HDAC1BCL2BCHEGID4POLB
SCHEMBL6188626 0.82 POLB (0.41) HDAC1BCL2GID4POLBNPC1
SCHEMBL6189993 0.82 HDAC1 (0.46) HDAC1POLBALOX12MEN1KMT2A
SCHEMBL6191680 0.81 GAA (0.41) HDAC1HTTNPSR1ADRB3ADRB1
SCHEMBL6187559 0.81 MEN1 (0.42) HDAC1BCHEPOLBNPC1ALDH1A1
SCHEMBL6188662 0.81 GAA (0.40) HDAC1POLBALDH1A1RAB9AADRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0979227-B1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA PHARMACEUTICAL (JP) 2005-11-16 EP disclosed
US-6352982-B1 TREATING DIABETES, OBESITY, OR INVETERATE DIARRHEA IN A MAMMAL WHICH COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF A COMPOUND OF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-05 US disclosed
EP-0979227-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS Takeda Chemical Industries, Ltd. (JP) 2000-02-16 EP disclosed
WO-1998047882-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-29 WO disclosed