Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6194127 | 0.91 | KCNH2 (0.51) | KCNH2ALDH1A1KMT2ATSHRHTT | |
| SCHEMBL5958447 | 0.90 | KCNH2 (0.69) | KCNH2ALDH1A1KMT2ATSHRHTT | |
| SCHEMBL6197011 | 0.87 | HRH1 (0.51) | KCNH2ALDH1A1KMT2ALMNACYP1A2 | |
| SCHEMBL6196921 | 0.85 | KCNH2 (0.49) | KCNH2ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL6192997 | 0.83 | KCNH2 (0.61) | KCNH2ALDH1A1KMT2ATSHRHTT | |
| SCHEMBL5958370 | 0.81 | KCNH2 (0.57) | KCNH2ALDH1A1KMT2AHTTLMNA | |
| SCHEMBL5958437 | 0.80 | KCNH2 (0.56) | KCNH2KMT2ATSHRHTTMAPT | |
| SCHEMBL5958409 | 0.78 | KCNH2 (0.54) | KCNH2ALDH1A1KMT2AHTTLMNA | |
| SCHEMBL5958585 | 0.77 | KCNH2 (0.54) | KCNH2ALDH1A1KMT2ATSHRHTT | |
| SCHEMBL6195921 | 0.77 | KMT2A (0.51) | KCNH2ALDH1A1KMT2ATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077373-A2 | TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD) | ASTRAZENECA AB (SE) | 2005-08-25 | — | — | WO | claimed |
| EP-1536790-A2 | OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | AstraZeneca AB (SE) | 2005-06-08 | — | — | EP | claimed |
| WO-2004014370-A2 | OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | ASTRAZENECA AB (SE) | 2004-02-19 | — | — | WO | claimed |
| WO-2005077373-A2 | TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD) | ASTRAZENECA AB (SE) | 2005-08-25 | — | — | WO | disclosed |
| EP-1536790-A2 | OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | AstraZeneca AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004014370-A2 | OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | ASTRAZENECA AB (SE) | 2004-02-19 | — | — | WO | disclosed |