Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7503569 | 0.85 | CYP3A4 (0.55) | CYP3A4CNR2MAPTCNR1TSHR | |
| SCHEMBL13469041 | 0.84 | CYP3A4 (0.54) | CYP3A4CNR2MAPTCNR1TSHR | |
| SCHEMBL1114850 | 0.84 | CYP3A4 (0.54) | CYP3A4CNR2MAPTLMNACRHBP | |
| SCHEMBL11738442 | 0.82 | CYP3A4 (0.60) | CYP3A4CNR2MAPTCNR1TSHR | |
| SCHEMBL3646180 | 0.82 | CYP3A4 (0.65) | CYP3A4CNR2CNR1TSHRALDH1A1 | |
| SCHEMBL12679975 | 0.82 | CYP3A4 (0.53) | CYP3A4CNR2CNR1TSHRALDH1A1 | |
| SCHEMBL1114715 | 0.82 | CYP3A4 (0.53) | CYP3A4CNR2CNR1TSHRALDH1A1 | |
| SCHEMBL20671836 | 0.81 | CYP3A4 (0.44) | CYP3A4CNR2MAPTLMNACRHBP | |
| SCHEMBL29204629 | 0.81 | CYP3A4 (0.44) | CYP3A4CNR2MAPTLMNACRHBP | |
| SCHEMBL12679972 | 0.81 | CYP3A4 (0.51) | CYP3A4CNR2MAPTLMNACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556361-A2 | 2-ALKYL-(2-AMINO-3-ARYL-PROPIONYL)-PIPERAZINE DERIVATIVES AND RELATED COMPOUNDS AS MELANOCORTIN RECEPTOR LIGANDS FOR THE TREATMENT OF OBESITY | THE PROCTER & GAMBLE COMPANY (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2004037797-A2 | 2 - ALKYL - (2 - AMINO - 3 - ARYL - PROPIONYL) - PIPERAZINE DERIVATIVES AND RELATED COMPOUNDS AS MELANOCORTIN RECEPTOR LIGANDS FOR THE TREATMENT OF OBESITY | THE PROCTER & GAMBLE COMPANY (US) | 2004-05-06 | — | — | WO | claimed |