Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.81 |
| ▸ | PDE1A | P54750 | 3/20 | 0.81 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.81 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.81 |
| ▸ | PDE2A | O00408 | 1/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.60 |
| ▸ | PDE6D | O43924 | 1/20 | 0.60 |
| ▸ | PDE8A | O60658 | 1/20 | 0.60 |
| ▸ | PDE9A | O76083 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | PDE6A | P16499 | 1/20 | 0.60 |
| ▸ | PDE6G | P18545 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | PDE6B | P35913 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198473 | 0.90 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL6196766 | 0.88 | PDE5A (0.81) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL6197392 | 0.86 | PDE5A (0.83) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7308922 | 0.86 | PDE5A (0.79) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL6195282 | 0.85 | PDE5A (0.84) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL6197049 | 0.84 | PDE5A (0.81) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL6193909 | 0.83 | PDE5A (0.80) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7311804 | 0.82 | PDE5A (0.73) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL3012495 | 0.82 | PDE5A (0.74) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL3026577 | 0.82 | PDE5A (0.74) | PDE5APDE1APDE1BPDE1CPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995751-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2005-06-29 | — | — | EP | disclosed |
| US-6407114-B1 | BENIGN PROSTATIC HYPERPLASIA, CARDIOVASCULAR, GASTROINTESTINAL AND RESPIRATORY DISORDER TREATMENT; ANTIASTHMATIC, ANTIALLERGEN, AND ANTIDIABETIC AGENTS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0995751-A2 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |