Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 13/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.65 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.42 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4867104 | 0.86 | AOC3 (0.75) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL4871983 | 0.85 | PIK3CD (0.60) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL4874846 | 0.83 | AOC3 (0.74) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL4874385 | 0.83 | AOC3 (0.77) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL4877874 | 0.83 | AOC3 (0.77) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL4867237 | 0.80 | AOC3 (0.73) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL4871812 | 0.80 | AOC3 (0.70) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL48857 | 0.79 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL14019515 | 0.79 | AOC3 (0.74) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 | |
| SCHEMBL4991674 | 0.79 | AOC3 (0.65) | PIK3CGPIK3CDPIK3CAPIK3CBAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587800-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS | Astellas Pharma Inc. (JP) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004067521-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-08-12 | — | — | WO | disclosed |