Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.49 |
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | CCND1 | P24385 | 4/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | CDK11A | Q9UQ88 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.44 |
| ▸ | CCR6 | P51684 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6197870 | 0.96 | CDK2 (0.46) | CDK2CCNA2CDK4CCND1CDK1 | |
| SCHEMBL6196326 | 0.92 | CDK2 (0.47) | CDK2CCNA2CDK4CCND1CDK1 | |
| SCHEMBL6197196 | 0.91 | CDK2 (0.53) | CDK2CCNA2CDK4CCND1CDK1 | |
| Hydrochloric Acid SCHEMBL6408432 | 0.91 | CDK2 (0.47) | CDK2CCNA2CDK4CCND1CDK1 | |
| SCHEMBL6193981 | 0.88 | CDK5 (0.52) | CDK2CCNA2CDK4CCND1CDK1 | |
| SCHEMBL6199575 | 0.86 | CDK4 (0.52) | CDK2CCNA2CDK4CCND1CDK1 | |
| SCHEMBL6197576 | 0.86 | CDK4 (0.50) | CDK2CCNA2CDK4CCND1CDK1 | |
| SCHEMBL6407196 | 0.86 | CDK4 (0.52) | CDK2CCNA2CDK4CCND1CDK1 | |
| SCHEMBL6408193 | 0.85 | CDK4 (0.49) | CDK2CCNA2CDK4CCND1CDK1 | |
| SCHEMBL6409070 | 0.85 | CDK2 (0.46) | CDK2CCNA2CDK4CCND1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597256-A1 | N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074283-A1 | N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2004-09-02 | — | — | WO | disclosed |