Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851901 | 0.95 | UTS2R (0.53) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL4859883 | 0.93 | UTS2R (0.56) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL4855333 | 0.92 | UTS2R (0.59) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL6198164 | 0.91 | UTS2R (0.58) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL4862789 | 0.91 | UTS2R (0.58) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL4859902 | 0.91 | UTS2R (0.58) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL6196505 | 0.89 | UTS2R (0.56) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL4861978 | 0.89 | UTS2R (0.56) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL6196165 | 0.89 | UTS2R (0.58) | UTS2RDRD2HTR2AADRA2ASLC6A2 | |
| SCHEMBL4862408 | 0.89 | UTS2R (0.52) | UTS2RDRD2HTR2AADRA2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499607-B1 | 4-(PIPERIDYL- AND PYRROLIDYL-ALKYL-UREIDO)-QUINOLINES AS UROTENSIN II RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-12-07 | — | — | EP | disclosed |