Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.76 |
| ▸ | HTR2A | P28223 | 18/20 | 0.76 |
| ▸ | HTR2B | P41595 | 7/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196761 | 1.00 | HTR2C (0.76) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| SCHEMBL6196204 | 0.90 | HTR2C (0.73) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| SCHEMBL6194880 | 0.87 | HTR2C (0.69) | HTR2CHTR2AHTR2B | |
| SCHEMBL905958 | 0.86 | HTR2C (1.00) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL6198201 | 0.85 | HTR2C (0.97) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL6198656 | 0.85 | HTR2C (0.97) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL6196249 | 0.85 | HTR2C (0.97) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| SCHEMBL6197389 | 0.85 | HTR2C (0.66) | HTR2CHTR2AHTR2B | |
| SCHEMBL27439441 | 0.84 | HTR2C (0.81) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL6195890 | 0.83 | HTR2C (0.79) | HTR2CHTR2AHTR2BHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990650-B1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6245796-B1 | NERVOUS SYSTEM DISORDERS; SEXUAL DISORDERS; SLEEP DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0990650-A1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-04-05 | — | — | EP | disclosed |