Hexamethylenebisacetamide

Hexamethylenebisacetamide

SCHEMBL61980

CC(=O)NCCCCCCNC(C)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 1.00
MAPK1 P28482 1/20 1.00
HIF1A Q16665 1/20 1.00
PAOX Q6QHF9 3/20 0.76
ADRA1A P35348 1/20 0.73
TSHR P16473 1/20 0.55
EPHX1 P07099 6/20 0.52
ALDH1A1 P00352 2/20 0.52
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
NAMPT P43490 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
CASP2 P42575 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1846096 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL10937726 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL14739632 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL6516953 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL14740196 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL14739904 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL1900654 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL1847535 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL14740132 1.00 KDM4E (1.00) KDM4EMAPK1HIF1APAOXADRA1A
SCHEMBL860791 0.97 KDM4E (0.94) KDM4EMAPK1HIF1APAOXADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9631 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
US-20250205310-A1 METHOD FOR REVERSING BODY-WIDE AGE-ASSOCIATED FUNCTIONAL CHANGES THE CHINESE UNIVERSITY OF HONG KONG (CN) 2025-06-26 US claimed
CN-119361799-A Diaphragm coated MOFs glass in-situ polymerization solid electrolyte and preparation method and application thereof 辽宁科技大学 2025-01-24 CN claimed
CN-119339984-A Metal-organic framework glass material for solidifying radionuclides and preparation method thereof 辽宁科技大学 2025-01-21 CN claimed
CN-119297419-A Air stable glassy metal-organic framework electrolyte material and preparation method thereof 辽宁科技大学 2025-01-10 CN claimed
US-20240343697-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2024-10-17 US claimed
CN-117996002-A Preparation method and application of sodium metal negative electrode modified by artificial solid electrolyte interface layer 河南易成新能源股份有限公司 2024-05-07 CN claimed
CN-117747793-A Method for preparing surface-modified layered oxide by low-temperature solid-liquid reaction and application thereof 郑州轻工业大学 2024-03-22 CN claimed
EP-2796112-B2 Degradable implantable medical devices ELIXIR MEDICAL CORP (US) 2023-08-09 EP claimed
EP-0359347-A2 Covalently-linked complexes and methods for enhanced cytotoxicity and imaging NEORX CORPORATION (US) 1990-03-21 EP claimed
EP-0043853-B1 INJECTION MOLDABLE AMIDE-IMIDE POLYMERS CONTAINING DIVALENT ALIPHATIC RADICALS DERIVED FROM ALIPHATIC DIAMINES AMOCO CORPORATION (US) 1985-11-13 EP claimed
EP-0043853-A4 INJECTION MOLDABLE AMIDE-IMIDE POLYMERS CONTAINING DIVALENT ALIPHATIC RADICALS DERIVED FROM ALIPHATIC DIAMINES. STANDARD OIL CO (US) 1982-05-28 EP claimed
US-4323493-A Injection moldable amide-imide polymers contaning divalent aliphatic radicals derived from aliphatic diamines STANDARD OIL COMPANY (INDIANA) (US) 1982-04-06 US claimed
US-4321357-A Injection moldable amide-imide polymers containing divalent aliphatic radicals derived from aliphatic diamines STANDARD OIL COMPANY (INDIANA) (US) 1982-03-23 US claimed
EP-0043853-A1 INJECTION MOLDABLE AMIDE-IMIDE POLYMERS CONTAINING DIVALENT ALIPHATIC RADICALS DERIVED FROM ALIPHATIC DIAMINES. STANDARD OIL CO (US) 1982-01-20 EP claimed
EP-0005476-B1 PROCESS FOR PREPARING HUMAN INTERFERON Dr. Karl Thomae GmbH (DE) 1981-12-30 EP claimed
WO-1981002015-A1 INJECTION MOLDABLE AMIDE-IMIDE POLYMERS CONTAINING DIVALENT ALIPHATIC RADICALS DERIVED FROM ALIPHATIC DIAMINES STANDARD OIL CO (US) 1981-07-23 WO claimed
US-4266024-A USING ALKYLENEDIAMIDES, DIMETHYL SULFOXIDE OR GLUCOCORTICOIDS AS STIMULATORS FOR LYMPHOID CELLS BOEHRINGER INGELHEIM GMBH (DE) 1981-05-05 US claimed
EP-0005476-A2 Process for preparing human interferon Dr. Karl Thomae GmbH (DE) 1979-11-28 EP claimed