Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.32 |
| ▸ | CDK4 | P11802 | 2/20 | 0.31 |
| ▸ | CCND1 | P24385 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219074 | 0.80 | CDK5 (0.46) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6408288 | 0.80 | ATM (0.37) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6409882 | 0.77 | CDK5 (0.34) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL3384258 | 0.75 | CDK5 (0.44) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6198783 | 0.75 | CDK5 (0.45) | CDK5CDK5R1CHEK1CDK4CCND1 | |
| SCHEMBL6195580 | 0.74 | CDK5 (0.40) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6196519 | 0.71 | CDK5 (0.42) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL3384838 | 0.65 | CDK5 (0.60) | CDK5CDK5R1CDK2ALDH1A1CCNA2 | |
| SCHEMBL6196947 | 0.64 | CDK5 (0.77) | CDK5CDK5R1CHEK1CDK4CCND1 | |
| SCHEMBL3386063 | 0.64 | CDK2 (0.43) | CDK5CDK5R1CDK4CCND1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597256-A1 | N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074283-A1 | N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2004-09-02 | — | — | WO | disclosed |