Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.54 |
| ▸ | HTR2C | P28335 | 10/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198930 | 0.91 | HTR2A (0.60) | HTR2AHTR2CNTRK1TP53RAF1 | |
| SCHEMBL6196811 | 0.90 | HTR2A (0.64) | HTR2AHTR2CNTRK1TP53GAA | |
| SCHEMBL6198557 | 0.89 | HTR2A (0.67) | HTR2AHTR2CCNR1GAASMN1; SMN2 | |
| SCHEMBL6200559 | 0.87 | HTR2A (0.58) | HTR2AHTR2CCNR1GAASMN1; SMN2 | |
| SCHEMBL6196617 | 0.85 | HTR2A (0.60) | HTR2AHTR2CRAF1BRAFKDR | |
| SCHEMBL6195174 | 0.84 | HTR2A (0.60) | HTR2AHTR2CNTRK1CNR1 | |
| SCHEMBL6196260 | 0.83 | HTR2A (0.58) | HTR2AHTR2CCNR1 | |
| SCHEMBL6199415 | 0.82 | HTR2A (0.64) | HTR2AHTR2CCNR1GAASMN1; SMN2 | |
| SCHEMBL6196200 | 0.81 | HTR2A (0.65) | HTR2AHTR2CTP53SMN1; SMN2KDR | |
| SCHEMBL6201643 | 0.79 | HTR2A (0.79) | HTR2AHTR2CCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |