Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 13/20 | 0.62 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.62 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.62 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.62 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13937984 | 0.85 | S1PR5 (0.56) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL13937989 | 0.85 | S1PR5 (0.56) | S1PR1S1PR3S1PR4S1PR5THRA | |
| SCHEMBL13937991 | 0.82 | S1PR1 (0.53) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL6181254 | 0.80 | S1PR1 (0.57) | S1PR1S1PR3S1PR4S1PR5HRH3 | |
| SCHEMBL6179863 | 0.80 | S1PR1 (0.57) | S1PR1S1PR3S1PR4S1PR5HRH3 | |
| SCHEMBL13937987 | 0.79 | S1PR1 (0.51) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL6179864 | 0.77 | S1PR1 (0.48) | S1PR1S1PR3S1PR4S1PR5HRH3 | |
| SCHEMBL6362290 | 0.77 | S1PR1 (0.48) | S1PR1S1PR3S1PR4S1PR5HRH3 | |
| SCHEMBL3909200 | 0.76 | S1PR1 (0.50) | S1PR1S1PR3S1PR4S1PR5HRH3 | |
| SCHEMBL3909199 | 0.76 | S1PR1 (0.50) | S1PR1S1PR3S1PR4S1PR5HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7479504-B2 | Edg receptor agonists | MERCK & CO., INC. (US) | 2009-01-20 | — | — | US | disclosed |
| US-7479504-B2 | Edg receptor agonists | MERCK & CO., INC. (US) | 2009-01-20 | — | — | US | disclosed |
| EP-1470137-A4 | EDG RECEPTOR AGONISTS | MERCK & CO INC (US) | 2005-06-15 | — | — | EP | disclosed |
| EP-1470137-A1 | EDG RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003062252-A1 | EDG RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2003-07-31 | — | — | WO | disclosed |